Once confined to the Amazon region, the Oropouche virus has emerged as a major public health threat across Latin America following a 2023 outbreak in Brazil that led to over 30,000 cases and its first confirmed deaths. Recent studies in Nature Medicine and Nature Health suggest the true disease burden is significantly underestimated, with an estimated 9.4 million historical infections. With no specific antiviral treatment available, management remains supportive alongside rigorous bite-preventio